Cell therapy in the heart

    Authors

    L. S. Abdelli; H. Merino; C. M. Rocher;D. K. Singla

    Comments

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    Abbreviated Journal Title

    Can. J. Physiol. Pharmacol.

    Keywords

    cardiomyopathy; cardiac myocytes; adult and embryonic stem cells; cell; transplantation therapy; clinical trials; ACUTE MYOCARDIAL-INFARCTION; PLURIPOTENT STEM-CELLS; BONE-MARROW-CELLS; LEFT-VENTRICULAR FUNCTION; IMPROVE CARDIAC-FUNCTION; ADIPOSE-TISSUE; ISCHEMIC-HEART; MYOBLAST TRANSPLANTATION; REGENERATION ENHANCEMENT; SKELETAL MYOBLASTS; Pharmacology & Pharmacy; Physiology

    Abstract

    Cell therapy is emerging as a new strategy to circumvent the adverse effects of heart disease. Many experimental and clinical studies investigating the transplantation of cells into the injured myocardium have yielded promising results. Moreover, data from these reports show that transplanted stem cells can engraft within the myocardium, differentiate into major cardiac cell types, and improve cardiac function. However, results from clinical trials show conflicting results. These trials demonstrate significant improvements in cardiac function for up to 6 months. However, these improved functions were diminished when examined at 18 months. In this review, we will discuss the current literature available on cell transplantation, covering studies ranging from animal models to clinical trials.

    Journal Title

    Canadian Journal of Physiology and Pharmacology

    Volume

    90

    Issue/Number

    3

    Publication Date

    1-1-2012

    Document Type

    Review

    Language

    English

    First Page

    307

    Last Page

    315

    WOS Identifier

    WOS:000301431400005

    ISSN

    0008-4212

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