Title

Skeletal Muscles of Ambulant Children with Duchenne Muscular Dystrophy: Validation of Multicenter Study of Evaluation with MR Imaging and MR Spectroscopy

Authors

Authors

S. C. Forbes; G. A. Walter; W. D. Rooney; D. J. Wang; S. Devos; J. Pollaro; W. Triplett; D. J. Lott; R. J. Willcocks; C. Senesac; M. J. Daniels; B. J. Byrne; B. Russman; R. S. Finkel; J. S. Meyer; H. L. Sweeney;K. Vandenborne

Comments

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Abbreviated Journal Title

Radiology

Keywords

FAT QUANTIFICATION; STIMULATED ECHOES; AGE; RELIABILITY; INVIVO; TISSUE; BOYS; Radiology, Nuclear Medicine & Medical Imaging

Abstract

Purpose: To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers. Materials and Methods: This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSA(max)), transverse relaxation time constant (T2), and lipid fraction were compared among centers in two-compartment coaxial phantoms and in two unaffected adult subjects who visited each center. Also, repeat MR measures were acquired twice on separate days in 30 boys with DMD (10 per center) and 10 unaffected boys. Coefficients of variation (CVs) were computed to examine the repeated-measure variabilities within and across centers. Results: CSA(max), T2 from MR imaging and MR spectroscopy, and lipid fraction were consistent across centers in the phantom (CV, <3%) and in the adult subjects who traveled to each site (CV, 2%-7%). High day-to-day reproducibility in MR measures was observed in boys with DMD (CSA(max), CV = 3.7% [25th percentile, 1.3%; 75th percentile, 5.1%]; contractile area, CV = 4.2% [25th percentile, 0.8%; 75th percentile, 4.9%]; MR imaging T2, CV = 3.1% [25th percentile, 1.2%; 75th percentile, 4.7%]; MR spectroscopy T2, CV = 3.9% [25th percentile, 1.5%; 75th percentile, 5.1%]; and lipid fraction, CV = 4.7% [25th percentile, 1.0%; 75th percentile, 5.3%]). Conclusion: The MR protocol implemented in this multicenter study achieved highly reproducible measures of lower extremity muscles across centers and from day to day in ambulatory boys with DMD. (C) RSNA, 2013

Journal Title

Radiology

Volume

269

Issue/Number

1

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

198

Last Page

207

WOS Identifier

WOS:000325000700022

ISSN

0033-8419

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