Title

Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection

Authors

Authors

L. L. Wong; S. M. Hirst; Q. N. Pye; C. M. Reilly; S. Seal;J. F. McGinnis

Comments

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Abbreviated Journal Title

PLoS One

Keywords

CERIUM OXIDE NANOPARTICLES; CELL-POPULATIONS; RCS RATS; DEGENERATION; PIGMENTOSA; PATHWAYS; SURFACES; DISEASE; ROD; Multidisciplinary Sciences

Abstract

Cerium oxide nanoparticles (nanoceria) possess catalytic and regenerative radical scavenging activities. The ability of nanoceria to maintain cellular redox balance makes them ideal candidates for treatment of retinal diseases whose development is tightly associated with oxidative damage. We have demonstrated that our stable water-dispersed nanoceria delay photoreceptor cell degeneration in rodent models and prevent pathological retinal neovascularization in vldlr mutant mice. The objectives of the current study were to determine the temporal and spatial distributions of nanoceria after a single intravitreal injection, and to determine if nanoceria had any toxic effects in healthy rat retinas. Using inductively-coupled plasma mass spectrometry (ICP-MS), we discovered that nanoceria were rapidly taken up by the retina and were preferentially retained in this tissue even after 120 days. We also did not observe any acute or long-term negative effects of nanoceria on retinal function or cytoarchitecture even after this long-term exposure. Because nanoceria are effective at low dosages, nontoxic and are retained in the retina for extended periods, we conclude that nanoceria are promising ophthalmic therapeutics for treating retinal diseases known to involve oxidative stress in their pathogeneses.

Journal Title

Plos One

Volume

8

Issue/Number

3

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

10

WOS Identifier

WOS:000316251100050

ISSN

1932-6203

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