Preventing bacterial growth on implanted device with an interfacial metallic film and penetrating X-rays
Abbreviated Journal Title
J. Mater. Sci.-Mater. Med.
SHELLFISH POISONING TOXINS; STAPHYLOCOCCUS-AUREUS; INFECTIONS; NANOPARTICLES; IRRADIATION; Engineering, Biomedical; Materials Science, Biomaterials
Device-related infections have been a big problem for a long time. This paper describes a new method to inhibit bacterial growth on implanted device with tissue-penetrating X-ray radiation, where a thin metallic film deposited on the device is used as a radio-sensitizing film for bacterial inhibition. At a given dose of X-ray, the bacterial viability decreases as the thickness of metal film (bismuth) increases. The bacterial viability decreases with X-ray dose increases. At X-ray dose of 2.5 Gy, 98 % of bacteria on 10 nm thick bismuth film are killed; while it is only 25 % of bacteria are killed on the bare petri dish. The same dose of X-ray kills 8 % fibroblast cells that are within a short distance from bismuth film (4 mm). These results suggest that penetrating X-rays can kill bacteria on bismuth thin film deposited on surface of implant device efficiently.
Journal of Materials Science-Materials in Medicine
"Preventing bacterial growth on implanted device with an interfacial metallic film and penetrating X-rays" (2015). Faculty Bibliography 2010s. 6395.