Title

Preventing bacterial growth on implanted device with an interfacial metallic film and penetrating X-rays

Authors

Authors

J. C. An; A. Sun; Y. Qiao; P. P. Zhang;M. Su

Comments

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Abbreviated Journal Title

J. Mater. Sci.-Mater. Med.

Keywords

SHELLFISH POISONING TOXINS; STAPHYLOCOCCUS-AUREUS; INFECTIONS; NANOPARTICLES; IRRADIATION; Engineering, Biomedical; Materials Science, Biomaterials

Abstract

Device-related infections have been a big problem for a long time. This paper describes a new method to inhibit bacterial growth on implanted device with tissue-penetrating X-ray radiation, where a thin metallic film deposited on the device is used as a radio-sensitizing film for bacterial inhibition. At a given dose of X-ray, the bacterial viability decreases as the thickness of metal film (bismuth) increases. The bacterial viability decreases with X-ray dose increases. At X-ray dose of 2.5 Gy, 98 % of bacteria on 10 nm thick bismuth film are killed; while it is only 25 % of bacteria are killed on the bare petri dish. The same dose of X-ray kills 8 % fibroblast cells that are within a short distance from bismuth film (4 mm). These results suggest that penetrating X-rays can kill bacteria on bismuth thin film deposited on surface of implant device efficiently.

Journal Title

Journal of Materials Science-Materials in Medicine

Volume

26

Issue/Number

2

Publication Date

1-1-2015

Document Type

Article

Language

English

First Page

6

WOS Identifier

WOS:000349402400008

ISSN

0957-4530

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