Keywords

COVID-19, Neurocognition, PASC, long COVID, Fatigue, Brain Fog, Cognitive Dysfunction

Abstract

The intent of this thesis is to provide an in-depth overview of the neurological manifestations associated with long COVID. The review aimed to assess the cognitive functioning symptoms associated with SARS-CoV-2 post-infection (PASC), investigate the potential mechanisms by which SARS-CoV-2 affects the nervous system, contributing to cognitive fatigue, brain fog, and cognitive dysfunction, and explore the parallels between SARS-CoV-2 and Alzheimer’s Disease. Neuroinflammation emerges as a shared element among these mechanisms, significantly impacting cognitive function. The parallels between COVID-19 and Alzheimer's Disease offer insights into how Alzheimer's affects cognition, aiding in understanding COVID-19's impact. The review underscores a notable gender disparity: women exhibit a greater susceptibility to the adverse effects of COVID-19, yet research in this domain remains limited. It advocates for further investigation into sex-specific differences and emphasizes the importance of understanding and spreading awareness about long COVID's impact on neurocognitive function and the nervous system, given the tendency among many medical professionals to underestimate its significance.

Thesis Completion Year

2024

Thesis Completion Semester

Spring

Thesis Chair

Villalba, Karina

College

College of Medicine

Department

Population Health Sciences

Thesis Discipline

Biomedical Sciences

Language

English

Access Status

Open Access

Length of Campus Access

None

Campus Location

Orlando (Main) Campus

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Rights Statement

In Copyright