Despite recent advances in development of improved cancer therapeutics one of the many clinical challenges is that patients often show resistance to cancer drugs. This invention provides evidence that an alternate method of treatment of cancer could be adopted for improved efficacy of existing therapies and /or treatment of drug resistant cancers. This study describes a novel functional relationship between two proteins that regulate proliferation of cells. Because these proteins are involved in cell growth, the amounts of these proteins are tightly regulated in normal cells however in cancer cells, abnormally increased amounts of these proteins are noted. One of the common methods for controlling abnormal growth of cancer cells is to inhibit production of these proteins. However, there are incidences of frequent development of resistance to the chemotherapeutic agents upon prolonged treatment, which sometimes is necessary to destroy all the cancer cells in the body. This study indicates that inhibitors of both proteins could be used instead of one, which will allow the use of lesser amounts of individual inhibitor to obtain the same effect.
Application Serial Number
Assignee at Issuance
Burnett School of Biomedical Sciences
Molecular Biology & Microbiology
Assignee at Filing
Nonprovisional Application Record
Chakrabarti, Ratna, "Co-targeting of aurora a kinase and lim kinase 1 for cancer therapy" (2014). UCF Patents. 102.