Abstract

Despite recent advances in development of improved cancer therapeutics one of the many clinical challenges is that patients often show resistance to cancer drugs. This invention provides evidence that an alternate method of treatment of cancer could be adopted for improved efficacy of existing therapies and /or treatment of drug resistant cancers. This study describes a novel functional relationship between two proteins that regulate proliferation of cells. Because these proteins are involved in cell growth, the amounts of these proteins are tightly regulated in normal cells however in cancer cells, abnormally increased amounts of these proteins are noted. One of the common methods for controlling abnormal growth of cancer cells is to inhibit production of these proteins. However, there are incidences of frequent development of resistance to the chemotherapeutic agents upon prolonged treatment, which sometimes is necessary to destroy all the cancer cells in the body. This study indicates that inhibitors of both proteins could be used instead of one, which will allow the use of lesser amounts of individual inhibitor to obtain the same effect.

Document Type

Patent

Patent Number

US 8,911,725

Application Serial Number

13/167,431

Issue Date

12-16-2014

Current Assignee

UCFRF

Assignee at Issuance

UCFRF

College

Burnett School of Biomedical Sciences

Department

Molecular Biology & Microbiology

Allowance Date

9-9-2013

Filing Date

6-23-2011

Assignee at Filing

UCFRF

Filing Type

Nonprovisional Application Record

Donated

no

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