Keywords
Vitamin D; epilepsy; antiepileptic drugs; neuroscience and epilepsy
Abstract
The link between diet and epilepsy in children has attracted a lot of attention among scholars of neuroscience and also pediatric institutions. This study examines the effect of Vitamin D (VD) in children with epileptic episodes. It is known that older antiepileptic drugs (AEDs) “cause adverse effects on both VD and calcium” (Gough et al., 1986), consequently leading to increased risk for fractures (Eadie, 1987; Devinsky et al., 1999). In a recent clinical trial it has been shown that VD supplement protects bone health in children taking AEDs (Viraraghaven et al., 2019). Therefore, adequate intake (AI) of VD in epileptic pediatric patients effectively improves bone health and control. A recent clinical study found that VD administration in drug resistant epilepsy did not help reducing the frequency of seizure (Tombini et al., 2018). However, VD seems to influence many brain activities (Cui et al., 2017) and a recent study showed decreased level of VD receptor expression in the peripheral blood of epileptic patients (Mazdeh et al., 2018). In this presentation, we will search the literature and discuss the mechanism of action of antiepileptic drugs and their effect on VD, the mechanism(s) of action of VD, its receptor and signaling pathway, and evaluate various effects of VD on the brain to better understand the role of this molecule as an adjuvant therapy in epilepsy.
Date Created
January 2019
STARS Citation
Hamood, Neda, "Hamood and Samsam_Vitamin D in Children with Epilepsy.pdf" (2019). EGS Content. 289.
https://stars.library.ucf.edu/egs_content/289
https://works.bepress.com/neda-hamood/1/download/