Abstract

In recent years, peroxidase mimic nanostructures have attracted special interest due to their low cost, high stability, and high catalytic activity. Herein, we demonstrate the use of Pd-Pt nanocubes (NCs) to achieve the rapid and sensitive colorimetric detection of ascorbic acid (AA), commonly known as vitamin C. The colored signal generated by the catalyzed oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) by the decomposition of hydrogen peroxide (H2O2) is quenched in the presence of AA based on its antioxidant property. This colorimetric method attains a detection limit of 0.40 µM and a linear range from 0 to 15 µM, with good linearity. To the best of our knowledge, the method proposed in this work presents the fastest AA detection among all the other colorimetric methods, with only a 3-minute reaction time. Furthermore, this method offers a simple procedure, cost-effectiveness, room temperature conditions and stability. As a proof-of-concept demonstration, the Pd-Pt NCs detection of AA was applied in human serum to corroborate its applicability in the biomedical field with the analysis of biological samples.

Notes

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Graduation Date

2020

Semester

Spring

Advisor

Xia, Xiaohu

Degree

Master of Science (M.S.)

College

College of Graduate Studies

Department

Nanoscience Technology Center

Degree Program

Nanotechnology

Format

application/pdf

Identifier

CFE0007938; DP0023073

URL

https://purls.library.ucf.edu/go/DP0023073

Language

English

Release Date

May 2023

Length of Campus-only Access

3 years

Access Status

Masters Thesis (Campus-only Access)

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