Title

Regulation Of Nadp-Malic Enzyme In The Eye-Antennal Disk Of Drosophila-Melanogaster Drosophila-Simulans Hybrids - Evidence For Cis-Regulation And Transregulation

Comments

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Abbreviated Journal Title

Genetics

Keywords

Genetics & Heredity

Abstract

Pattern regulation of malic enzyme (ME) distribution in D. melanogaster/D. simulans (mel/sim) hybrid eye-antennal discs was investigated. Both cis- and trans-regulation of the spatial distribution pattern was observed within the eye portion of the disc complex. D. simulans possesses gene(s) that operate in trans in the hybrids to suppress ME staining along the morphogenetic furrow, a region that always stains in D. melanogaster. ME structural genes of both species were expressed in cis within the ommatidial preclusters and clusters of the hybrids. Malic enzyme was not expressed elsewhere in the eye disc of either species. Restoration of the D. melanogaster furrow pattern element occurred in partial hybrids that were homozygous for the D. melanogaster 3R where the structural gene resides. Therefore, a dominant gene(s) in the D. simulans 3R suppresses the D. melanogaster furrow pattern, while a recessive gene(s) in the D. melanogaster 3R restores the pattern when the trans-suppressor is removed. These conclusions agree with those found for regulation of aldehyde oxidase distribution in D. melanogaster/D. simulans hybrid wing discs.

Journal Title

Genetics

Volume

115

Issue/Number

2

Publication Date

1-1-1987

Document Type

Article

Language

English

First Page

277

Last Page

281

WOS Identifier

WOS:A1987G128600009

ISSN

0016-6731

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