An improved synthesis of O-benzoyl protected hydroxamates

    Authors

    Q. X. H. Wang; J. King;O. Phanstiel

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    J. Org. Chem.

    Keywords

    BIOLOGICAL PROPERTIES; BIOSYNTHESIS; SIDEROPHORE; NANNOCHELIN; INHIBITORS; Chemistry, Organic

    Abstract

    Several primary amines (R-NH2) were converted to their corresponding O-benzoyl protected hydroxamates under biphasic conditions. The intermediate (benzoyloxy)amines (R-NHOCOPh) were generated using benzoyl peroxide dissolved in CH2Cl2 and an aqueous carbonate buffer (pH 10.5) at room temperature. Subsequent acylation with R'COCl gave the protected hydroxamates (R'CONROCOPh) in good overall yields (56-89%).

    Journal Title

    Journal of Organic Chemistry

    Volume

    62

    Issue/Number

    23

    Publication Date

    1-1-1997

    Document Type

    Article

    Language

    English

    First Page

    8104

    Last Page

    8108

    WOS Identifier

    WOS:A1997YG45200036

    ISSN

    0022-3263

    Share

    COinS