Title

The application of disubstituted vinylogous iminium salts and related synthons to the regiocontrolled preparation of unsymmetrical 2,3,4-trisubstituted pyrroles

Authors

Authors

J. T. Gupton; K. E. Krumpe; B. S. Burnham; K. A. Dwornik; S. A. Petrich; K. X. Du; M. A. Bruce; P. Vu; M. Vargas; K. M. Keertikar; K. N. Hosein; C. R. Jones;J. A. Sikorski

Comments

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Abbreviated Journal Title

Tetrahedron

Keywords

pyrroles; vinylogous iminium salts; vinylogous amides; chloroenals; RIGIDIN; Chemistry, Organic

Abstract

Reactions of 2,3-disubstituted chloropropeniminium salts and related synthons with ethyl glycinate, ethyl N-methylglycinate, and ethyl N-benzylglycinate have been studied tinder acidic, basic and neutral conditions. Such reactions have resulted in efficient and selective methodology for the synthesis of unsymmetrical 2,3,4-trisubstituted pyrrole systems. (C) 1998 Elsevier Science Ltd. All rights reserved.

Journal Title

Tetrahedron

Volume

54

Issue/Number

20

Publication Date

1-1-1998

Document Type

Article

Language

English

First Page

5075

Last Page

5088

WOS Identifier

WOS:000073334600004

ISSN

0040-4020

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