Abbreviated Journal Title
Antimicrob. Agents Chemother.
RIBONUCLEOTIDE REDUCTASE INHIBITOR; DIDOX; Microbiology; Pharmacology & Pharmacy
Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria parasite.
Antimicrobial Agents and Chemotherapy
Holland, Kevin P.; Elford, Howard L.; Bracchi, Valerie; Annis, Charles G.; Schuster, Sheldon M.; and Chakrabarti, Debopam, "Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives" (1998). Faculty Bibliography 1990s. 2282.