Identification Of A Family Of Rab G-Proteins In Plasmodium Falciparum And A Detailed Characterisation Of Pfrab6

    Authors

    F. A. deCastro; G. E. Ward; R. Jambou; G. Attal; V. Mayau; G. Jaureguiberry; C. BraunBreton; D. Chakrabarti;G. Langsley

    Comments

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    Abbreviated Journal Title

    Mol. Biochem. Parasitol.

    Keywords

    Rab GTPases; Rab6, traffic; secretion; Plasmodium falciparum; malaria; BINDING PROTEIN; GOLGI; TRANSPORT; PARASITE; GTPASES; GLYCOSYLATION; ERYTHROCYTES; EXPRESSION; CLONING; STAGE; Biochemistry & Molecular Biology; Parasitology

    Abstract

    As a first step towards developing a set of compartment-specific probes for studying protein trafficking in the malaria-infected erythrocyte, we describe here a family of Plasmodium falciparum Rab proteins. We characterise in detail P. falciparum Rab6 (PfRab6) a marker which in other cells is specific for the Golgi/trans Golgi network. Although PfRab6 mRNA is expressed throughout the intraerythrocytic cycle, maximal expression occurs at the trophozoite stage. Immunofluorescence microscopy shows that the distribution of PfRab6 changes during the final stages of parasite maturation, coalescing into multiple foci, each of which is associated with the nucleus of a forming daughter parasite.

    Journal Title

    Molecular and Biochemical Parasitology

    Volume

    80

    Issue/Number

    1

    Publication Date

    1-1-1996

    Document Type

    Article

    Language

    English

    First Page

    77

    Last Page

    88

    WOS Identifier

    WOS:A1996VG23700007

    ISSN

    0166-6851

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