Title

Protection from radiation-induced pneumonitis using cerium oxide nanoparticles

Authors

Authors

J. Colon; L. Herrera; J. Smith; S. Patil; C. Komanski; P. Kupelian; S. Seal; D. W. Jenkins;C. H. Baker

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Nanomed.-Nanotechnol. Biol. Med.

Keywords

Radioprotection; Nanoparticles; Pneumonitis; Quality of life; CELLS; Nanoscience & Nanotechnology; Medicine, Research & Experimental

Abstract

In an effort to combat the harmful effects of radiation exposure, we propose that rare-earth cerium oxide (CeO(2)) nanoparticles (free-radical scavengers) protect normal tissue from radiation-induced damage. Preliminary studies suggest that these nanoparticles may be a therapeutic regenerative nanomedicine that will scavenge reactive oxygen species, which are responsible for radiation-induced cell damage. The effectiveness of CeO(2) nanoparticles in radiation protection in murine models during high-dose radiation exposure is investigated, with the ultimate goal of offering a new approach to radiation protection, using nanotechnology. We show that CeO(2) nanoparticles are well tolerated by live animals, and they prevent the onset of radiation-induced pneumonitis when delivered to live animals exposed to high doses of radiation. In the end, these studies provide a tremendous potential for radioprotection and can lead to significant benefits for the preservation of human health and the quality of life for humans receiving radiation therapy. (C) 2009 Elsevier Inc. All rights reserved.

Journal Title

Nanomedicine-Nanotechnology Biology and Medicine

Volume

5

Issue/Number

2

Publication Date

1-1-2009

Document Type

Article

Language

English

First Page

225

Last Page

231

WOS Identifier

WOS:000267418000016

ISSN

1549-9634

Share

COinS