Protection from radiation-induced pneumonitis using cerium oxide nanoparticles

    Authors

    J. Colon; L. Herrera; J. Smith; S. Patil; C. Komanski; P. Kupelian; S. Seal; D. W. Jenkins;C. H. Baker

    Comments

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    Abbreviated Journal Title

    Nanomed.-Nanotechnol. Biol. Med.

    Keywords

    Radioprotection; Nanoparticles; Pneumonitis; Quality of life; CELLS; Nanoscience & Nanotechnology; Medicine, Research & Experimental

    Abstract

    In an effort to combat the harmful effects of radiation exposure, we propose that rare-earth cerium oxide (CeO(2)) nanoparticles (free-radical scavengers) protect normal tissue from radiation-induced damage. Preliminary studies suggest that these nanoparticles may be a therapeutic regenerative nanomedicine that will scavenge reactive oxygen species, which are responsible for radiation-induced cell damage. The effectiveness of CeO(2) nanoparticles in radiation protection in murine models during high-dose radiation exposure is investigated, with the ultimate goal of offering a new approach to radiation protection, using nanotechnology. We show that CeO(2) nanoparticles are well tolerated by live animals, and they prevent the onset of radiation-induced pneumonitis when delivered to live animals exposed to high doses of radiation. In the end, these studies provide a tremendous potential for radioprotection and can lead to significant benefits for the preservation of human health and the quality of life for humans receiving radiation therapy. (C) 2009 Elsevier Inc. All rights reserved.

    Journal Title

    Nanomedicine-Nanotechnology Biology and Medicine

    Volume

    5

    Issue/Number

    2

    Publication Date

    1-1-2009

    Document Type

    Article

    Language

    English

    First Page

    225

    Last Page

    231

    WOS Identifier

    WOS:000267418000016

    ISSN

    1549-9634

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