Title

Plant-made vaccine antigens and biopharmaceuticals

Authors

Authors

H. Daniell; N. D. Singh; H. Mason;S. J. Streatfield

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Trends Plant Sci.

Keywords

B SURFACE-ANTIGEN; TRANSGENIC TOBACCO PLANTS; HIGH-LEVEL EXPRESSION; VIRUS-LIKE PARTICLES; SYSTEMIC IMMUNE-RESPONSE; FIBROBLAST-GROWTH-FACTOR; HIGH-YIELD EXPRESSION; LACTUCA-SATIVA L.; HEPATITIS-B; ORAL IMMUNIZATION; Plant Sciences

Abstract

Plant cells are ideal bioreactors for the production and oral delivery of vaccines and biopharmaceuticals, eliminating the need for expensive fermentation, purification, cold storage, transportation and sterile delivery. Plant-made vaccines have been developed for two decades but none has advanced beyond Phase I. However, two plant-made biopharmaceuticals are now advancing through Phase II and Phase III human clinical trials. In this review, we evaluate the advantages and disadvantages of different plant expression systems (stable nuclear and chloroplast or transient viral) and their current limitations or challenges. We provide suggestions for advancing this valuable concept for clinical applications and conclude that greater research emphasis is needed on large-scale production, purification, functional characterization, oral delivery and preclinical evaluation.

Journal Title

Trends in Plant Science

Volume

14

Issue/Number

12

Publication Date

1-1-2009

Document Type

Review

Language

English

First Page

669

Last Page

679

WOS Identifier

WOS:000272855700005

ISSN

1360-1385

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