PEGylated Nanoceria as Radical Scavenger with Tunable Redox Chemistry

    Authors

    A. S. Karakoti; S. Singh; A. Kumar; M. Malinska; Svnt Kuchibhatla; K. Wozniak; W. T. Self;S. Seal

    Abbreviated Journal Title

    J. Am. Chem. Soc.

    Keywords

    HOMOGENEOUS PRECIPITATION METHOD; CERIUM OXIDE NANOPARTICLES; POLYETHYLENE-GLYCOL; SUPEROXIDE-DISMUTASE; FINE PARTICLES; CONJUGATE; DELIVERY; Chemistry, Multidisciplinary

    Abstract

    We report the direct synthesis of cerium oxide nanoparticles (CNPs) in polyethylene glycol (PEG) based solutions with efficient radical scavenging properties. Synthesis of CNPs in PEG demonstrated a concentration dependent (of PEG) redox activity characterized by UV-visible spectroscopy. PEGylated CNPs acted as efficient radical scavengers, and superoxide dismutase (SOD) activity of CNPs synthesized in various concentration of PEG did not reduce compared to bare nanoceria. In addition to superoxide, PEGylated nanoceria demonstrated quenching of peroxide radicals as welt. It was observed that the reaction with hydrogen peroxide leads to the formation of a charge transfer complex governed by the concentration of PEG. The stability of the charge transfer complex provides the tunable oxidation state of CNPs. The stability of this complex influences the regenerative capacity of the active 3+ oxidation state of CNPs. The cell viability as well as SOD activity of PEGylated CNPs is compared to those of bare CNPs, and the differences are outlined.

    Journal Title

    Journal of the American Chemical Society

    Volume

    131

    Issue/Number

    40

    Publication Date

    1-1-2009

    Document Type

    Article

    Language

    English

    First Page

    14144

    Last Page

    14145

    WOS Identifier

    WOS:000271271500009

    ISSN

    0002-7863

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