Title
Prostasin inhibits cell invasion in human choriocarcinomal JEG-3 cells
Abbreviated Journal Title
Histochem. Cell Biol.
Keywords
Prostasin; Cell invasion; Choriocarcinomal JEG-3 cell; MMPs/TIMPs; Integrins; TROPHOBLAST INVASION; SERINE-PROTEASE; MATRIX METALLOPROTEINASE-26; BLOOD-PRESSURE; RHESUS-MONKEY; 1ST TRIMESTER; GAMMA-SUBUNIT; EXPRESSION; IMPLANTATION; ACTIVATION; Cell Biology; Microscopy
Abstract
Controlled invasion of the uterine wall by the trophoblast cells is pivotal for the successful pregnancy, and various kinds of protease are involved in this process. Serine protease prostasin has been shown to participate in the proteolytic activation of epithelial sodium channel as well as cleavage of epidermal growth factor receptor extracellular domain in human epithelial cells. Its physiological significance in human placentation has been suggested but not validated. In the present study, we found that prostasin was expressed at a relatively high level in human placenta trophoblasts in early pregnant weeks. In the in vitro cultured human choriocarcinomal JEG-3 cells, treatment with functional antibody against prostasin led to promotion in cell invasion capability, as well as increase in the production of MMP-2, MMP-26, TIMP-1, and TIMP-4. Our data indicated that this serine protease may function as an invasion suppressor in human trophoblast, participating in the invasion-restrictive regulation of trophoblasts to avoid their over-penetration into the uterine wall.
Journal Title
Histochemistry and Cell Biology
Volume
132
Issue/Number
6
Publication Date
1-1-2009
Document Type
Article
Language
English
First Page
639
Last Page
646
WOS Identifier
ISSN
0948-6143
Recommended Citation
"Prostasin inhibits cell invasion in human choriocarcinomal JEG-3 cells" (2009). Faculty Bibliography 2000s. 1849.
https://stars.library.ucf.edu/facultybib2000/1849
Comments
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