Evolution of Drosophila ribosomal protein gene core promoters

    Authors

    X. T. Ma; K. Y. Zhang;X. M. Li

    Comments

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    Abstract

    The coordinated expression of ribosornal protein genes (RPGs) has been well documented in many species. Previous analyses of RPG promoters focus only on Fungi and mammals. Recognizing this gap and using a comparative genomics approach, we utilize a motif-finding algorithm that incorporates cross-species conservation to identify several significant motifs in Drosophila RPG promoters. As a result, significant differences of the enriched motifs in RPG promoter are found among Drosophila, Fungi, and mammals, demonstrating the evolutionary dynamics of the ribosomal gene regulatory network. We also report a motif present in similar numbers of RPGs among Drosophila species which does not appear to be conserved at the individual RPG gene level. A module-wise stabilizing selection theory is proposed to explain this observation. Overall, our results provide significant insight into the fast-evolving nature of transcriptional regulation in the RPG module. (c) 2008 Elsevier B.V. All rights reserved.

    Journal Title

    Gene

    Volume

    432

    Issue/Number

    1-2

    Publication Date

    1-1-2009

    Document Type

    Article

    First Page

    54

    Last Page

    59

    WOS Identifier

    WOS:000263712400007

    ISSN

    0378-1119

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