A comparative analysis of two different sets of Y-chromosome short tandem repeats (Y-STRs) on a common population panel

    Authors

    J. L. Maybruck; E. Hanson; J. Ballantyne; B. Budowle;P. A. Fuerst

    Comments

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    Abbreviated Journal Title

    Forensic Sci. Int.-Genet.

    Keywords

    Forensic science; Short tandem repeats; Microsatellites; Y-chromosome; Y-STR; FORENSIC CASEWORK; X-CHROMOSOME; INTERNATIONAL SOCIETY; GENOTYPING; SYSTEM; DNA COMMISSION; UNITED-STATES; LOCI; VALIDATION; HAPLOTYPES; MICROSATELLITES; Genetics & Heredity; Medicine, Legal

    Abstract

    A comparative analysis of two Y-STR loci sets was conducted on a population sample of 224 individuals, 114 Caucasians and 110 African Americans. One set of loci, designated the OSU 10-locus set, comprises variable, single copy, male-specific loci that are dispersed across the Y-chromosome. Parallel evaluations were performed using the 10 Y-chromosome loci most frequently used for forensic analysis, the loci chosen as the SWGDAM Y-STR loci. The OSU 10-locus set had a greater average number of alleles per locus and higher average gene diversity than the SWGDAM loci. The OSU 10-locus set found 220 unique haplotypes in 224 individuals. In similar to 6000 pairwise haplotype comparisons for each population with each set of loci, the OSU 10-locus set also yielded a greater average number of allelic differences per pair than the SWGDAM loci. Finally, the overall linkage disequilibrium levels were lower for the OSU 10-locus set in the Caucasian population. In general, the OSU 10-locus set revealed a higher power of discrimination than the SWGDAM set. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

    Journal Title

    Forensic Science International-Genetics

    Volume

    4

    Issue/Number

    1

    Publication Date

    1-1-2009

    Document Type

    Article

    Language

    English

    First Page

    11

    Last Page

    20

    WOS Identifier

    WOS:000273147500002

    ISSN

    1872-4973

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