Title

Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy

Authors

Authors

H. Zhang; H. Y. Lin; Q. Yang; H. X. Wang; K. X. Chai; L. M. Chen;C. Zhu

Comments

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Abbreviated Journal Title

J. Histochem. Cytochem.

Keywords

prostasin; protease nexin-1; ovary; primate; PLASMINOGEN-ACTIVATOR; GRANULOSA-CELLS; MACACA-MULATTA; INHIBITORS; CANCER; RAT; LOCALIZATION; IMPLANTATION; PURIFICATION; KALLIKREINS; Cell Biology

Abstract

Serine proteases and their cognate serpin-class inhibitors are involved in the controlled proteolytic events during follicular development, ovulation, formation, and maintenance of the corpus luteum (CL). In this study, we investigated the expression pat-terns of prostasin serine protease and protease nexin-1 (PN-1), a serine protease inhibitor also called serpin-E2, in rhesus monkey ovaries during the menstrual cycle and early pregnancy, by using in situ hybridization and immunohistochemistry. Expression of prostasin was localized in oocyte, granulosa cells, and/or theca cells of early antral follicles and antral follicles, with high levels observed in preovulatory follicles. Prostasin was also localized at high levels of abundance in the CL during the menstrual cycle and early pregnancy. During the menstrual cycle, PN-1 was coordinately localized with prostasin in oocytes, granulosa cells, and theca cells of antral follicles and preovulatory follicles and in the CL. In addition, the PN-1 expression level in macaque CL during early pregnancy increased as pregnancy proceeded. We propose that prostasin may be involved in follicular development, ovulation, and CL formation, whereas PN-1 may be present to regulate the proteolysis in these processes.

Journal Title

Journal of Histochemistry & Cytochemistry

Volume

55

Issue/Number

12

Publication Date

1-1-2007

Document Type

Article

Language

English

First Page

1237

Last Page

1244

WOS Identifier

WOS:000250997400007

ISSN

0022-1554

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