Title

New insights into mitochondrial structure during cell death

Authors

Authors

G. Perkins; E. Bossy-Wetzel;M. H. Ellisman

Comments

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Abbreviated Journal Title

Exp. Neurol.

Keywords

Apoptosis; Cardiolipin; Crista junction; Cristae remodeling; Cytochrome; c; Electron tomography; Mitochondria; Neurodegeneration; OPA1; CYTOCHROME-C RELEASE; AMYOTROPHIC-LATERAL-SCLEROSIS; PAINFUL PERIPHERAL; NEUROPATHY; SUPEROXIDE-DISMUTASE SOD1; SYNUCLEIN TRANSGENIC MICE; DYNAMIN-RELATED GTPASE; INNER-MEMBRANE; OXIDATIVE STRESS; ENDOPLASMIC-RETICULUM; ELECTRON TOMOGRAPHY; Neurosciences

Abstract

Mitochondria play a pivotal role in the cascade of events associated with cell death pathways that are involved with several forms of neurodegeneration. Recent findings show that in the Bax/Bak-dependent pathway of apoptosis, the release of cytochrome c from mitochondria is a consequence of two carefully coordinated events: opening of crista junctions triggered by OPA1 oligomer disassembly and formation of outer membrane pores. Both steps are necessary for the complete release of pro-apoptotic proteins. The remodeling of mitochrondrial structure accompanies this pathway, including mitochondrial fission, and cristae and crista junction alterations. Yet, there is controversy surrounding the timing of certain remodeling events and whether they are necessary early events required for the release of pro-apoptotic factors or are simply a downstream after-effect. Here, we analyze the current knowledge of mitochondrial remodeling during cell death and discuss what structural alterations Occur to this organelle during neurodegeneration, focusing Oil the higher resolution structural correlates obtained by electron microscopy and electron tomography. (C) 2009 Elsevier Inc. All rights reserved.

Journal Title

Experimental Neurology

Volume

218

Issue/Number

2

Publication Date

1-1-2009

Document Type

Review

Language

English

First Page

183

Last Page

192

WOS Identifier

WOS:000268117400003

ISSN

0014-4886

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