Embryonic Stem Cells in Cardiac Repair and Regeneration

    Authors

    D. K. Singla

    Comments

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    Abbreviated Journal Title

    Antioxid. Redox Signal.

    Keywords

    ACUTE MYOCARDIAL-INFARCTION; BONE-MARROW-CELLS; FUNCTIONAL IMPROVEMENT; INHIBIT APOPTOSIS; HUMAN BLASTOCYSTS; PROGENITOR CELLS; ISCHEMIC-HEART; GROWTH-FACTORS; IN-VITRO; TRANSPLANTATION; Biochemistry & Molecular Biology; Endocrinology & Metabolism

    Abstract

    Cell transplantation is a subject of fast-growing research with a potential of a therapeutic approach for the treatment of heart diseases. Clinical applications require preparation of large number of donor cells. Stem cell studies published to date demonstrate that scientists have not reached the general consensus to use an optimal cell type for better cardiac repair and regeneration. We used embryonic stem (ES) cells and their released factors for cardiac repair and regeneration. The major concern of cardiac regeneration with stem cells includes engraftment, differentiation, and teratoma formation after ES cell transplantation. Our current knowledge of ES cell transplantation in the heart is very limited. This review discusses the use of various growth factors to enhance ES cells engraftment and differentiation, as well as the issue of teratoma formation. Antioxid. Redox Signal. 11, 1857-1863.

    Journal Title

    Antioxidants & Redox Signaling

    Volume

    11

    Issue/Number

    8

    Publication Date

    1-1-2009

    Document Type

    Review

    Language

    English

    First Page

    1857

    Last Page

    1863

    WOS Identifier

    WOS:000267488900008

    ISSN

    1523-0864

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