Staphylococcus aureus nasal carriage and its contributing factors

    Authors

    K. Sivaraman; N. Venkataraman;A. M. Cole

    Comments

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    Abbreviated Journal Title

    Future Microbiol.

    Keywords

    antimicrobial peptides; clumping factor; comparative genomics; epidemiology; IsdA; molecular typing; nasal carriage; Staphylococcus; aureus; TagO; type VII secretion system; FIELD GEL-ELECTROPHORESIS; CLUMPING FACTOR-B; TANDEM-REPEAT ANALYSIS; METHICILLIN-RESISTANT; STREPTOCOCCUS-PNEUMONIAE; GENOME SEQUENCE; HEALTHY-ADULTS; BETA-DEFENSINS; HUMAN SKIN; COLONIZATION; Microbiology

    Abstract

    Staphylococcus aureus is a medically important pathogen that is often acquired from hospital settings (nosocomial) as well as from the community (community acquired). Bacteria that reside in anterior nares of hosts serve as reservoirs for both the spread of the pathogen and predispose the host to subsequent infections, Here, we will review the extent and variability of nasal carriage, and the possible causative factors - both from the host and the bacterium. We also discuss the existing molecular typing techniques used for studying variations among strains of S. aureus. Finally, we discuss the possible areas of studies that are open in this field. Given the pathogen's importance in healthcare setting, such areas of study vary vastly, from fundamental research to applied medical care and use of alternative medical regimes for control of S. aureus nasal carriage. Unsurprisingly, our conclusions also underscore the importance of making policy decisions based on local ethnic and socioeconomic population structure.

    Journal Title

    Future Microbiology

    Volume

    4

    Issue/Number

    8

    Publication Date

    1-1-2009

    Document Type

    Review

    Language

    English

    First Page

    999

    Last Page

    1008

    WOS Identifier

    WOS:000271143100012

    ISSN

    1746-0913

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