Title

Staphylococcus aureus nasal carriage and its contributing factors

Authors

Authors

K. Sivaraman; N. Venkataraman;A. M. Cole

Comments

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Abbreviated Journal Title

Future Microbiol.

Keywords

antimicrobial peptides; clumping factor; comparative genomics; epidemiology; IsdA; molecular typing; nasal carriage; Staphylococcus; aureus; TagO; type VII secretion system; FIELD GEL-ELECTROPHORESIS; CLUMPING FACTOR-B; TANDEM-REPEAT ANALYSIS; METHICILLIN-RESISTANT; STREPTOCOCCUS-PNEUMONIAE; GENOME SEQUENCE; HEALTHY-ADULTS; BETA-DEFENSINS; HUMAN SKIN; COLONIZATION; Microbiology

Abstract

Staphylococcus aureus is a medically important pathogen that is often acquired from hospital settings (nosocomial) as well as from the community (community acquired). Bacteria that reside in anterior nares of hosts serve as reservoirs for both the spread of the pathogen and predispose the host to subsequent infections, Here, we will review the extent and variability of nasal carriage, and the possible causative factors - both from the host and the bacterium. We also discuss the existing molecular typing techniques used for studying variations among strains of S. aureus. Finally, we discuss the possible areas of studies that are open in this field. Given the pathogen's importance in healthcare setting, such areas of study vary vastly, from fundamental research to applied medical care and use of alternative medical regimes for control of S. aureus nasal carriage. Unsurprisingly, our conclusions also underscore the importance of making policy decisions based on local ethnic and socioeconomic population structure.

Journal Title

Future Microbiology

Volume

4

Issue/Number

8

Publication Date

1-1-2009

Document Type

Review

Language

English

First Page

999

Last Page

1008

WOS Identifier

WOS:000271143100012

ISSN

1746-0913

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