Milestones in chloroplast genetic engineering: an environmentally friendly era in biotechnology

    Authors

    H. Daniell; M. S. Khan;L. Allison

    Comments

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    Abbreviated Journal Title

    Trends Plant Sci.

    Keywords

    GREEN FLUORESCENT PROTEIN; TOBACCO CHLOROPLASTS; PLASTID TRANSFORMATION; SELECTABLE MARKER; BACILLUS-THURINGIENSIS; TRANSIENT EXPRESSION; BIOSYNTHETIC-PATHWAY; BIOLISTIC DELIVERY; HIGHER-PLANTS; RESISTANCE; Plant Sciences

    Abstract

    Chloroplast genomes defied the laws of Mendelian inheritance at the dawn of plant genetics, and continue to defy the mainstream approach to biotechnology, leading the field in an environmentally friendly direction. Recent success in engineering the chloroplast genome for resistance to herbicides, insects, disease and drought, and for production of biopharmaceuticals, has opened the door to a new era in biotechnology. The successful engineering of tomato chromoplasts for high-level transgene expression in fruits, coupled to hyper-expression of vaccine antigens, and the use of plant-derived antibiotic-free selectable markers, augur well for oral delivery of edible vaccines and biopharmaceuticals that are currently beyond the reach of those who need them most.

    Journal Title

    Trends in Plant Science

    Volume

    7

    Issue/Number

    2

    Publication Date

    1-1-2002

    Document Type

    Review

    Language

    English

    First Page

    84

    Last Page

    91

    WOS Identifier

    WOS:000173787500010

    ISSN

    1360-1385

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