Anticancer and antithrombin activity of Russian plants

    Authors

    E. A. Goun; V. M. Petrichenko; S. U. Solodnikov; T. V. Suhinina; M. A. Kline; G. Cunningham; C. Nguyen;H. Miles

    Abbreviated Journal Title

    J. Ethnopharmacol.

    Keywords

    antithrombin activity; anticancer activity; mouse leukemia (L1210); Russian plants; Quercus robur; Sanguisorba officinalis; TANACETUM-VULGARE L; ANTIOXIDATIVE ACTIVITY; ROSMARINIC ACID; SESQUITERPENE; CONSTITUENTS; LAMIACEAE; SKELETON; LACTONE; Plant Sciences; Chemistry, Medicinal; Integrative & Complementary; Medicine; Pharmacology & Pharmacy

    Abstract

    A chromogenic bioassay was utilized to determine the antithrombin activity of the methylene chloride and methanol extracts prepared from forty-five plants of Russia. Mouse leukemia cells (L1210) were utilized to screen these extracts for activity against cancer. The results indicated that eight plant extracts demonstrated 90% or higher activity in the inhibition of thrombin. Also, nine methanol extracts demonstrated activity of 90% or higher in the inhibition of mouse leukemia L1210 cells. The methanol extracts of Quercus robur and Sanguisorba afficinalis demontrated high activity against both thrombin and cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

    Journal Title

    Journal of Ethnopharmacology

    Volume

    81

    Issue/Number

    3

    Publication Date

    1-1-2002

    Document Type

    Article

    Language

    English

    First Page

    337

    Last Page

    342

    WOS Identifier

    WOS:000177488400006

    ISSN

    0378-8741

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