Perspectives on the use of gene therapy for chronic joint diseases

    Authors

    S. C. Ghivizzani; E. Gouze; J. N. Gouze; J. D. Kay; M. L. Bush; R. S. Watson; P. P. Levings; D. M. Nickerson; P. T. Colahan; P. D. Robbins;C. H. Evans

    Comments

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    Abbreviated Journal Title

    Curr. Gene Ther.

    Keywords

    arthritis; gene therapy; adenovirus; adeno-associated virus; lentivirus; osteoarthritis; interleukin-1; tumor necrosis factor; COLLAGEN-INDUCED ARTHRITIS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; TUMOR-NECROSIS-FACTOR; ADJUVANT-INDUCED ARTHRITIS; GROWTH-FACTOR-BETA; EARLY EXPERIMENTAL OSTEOARTHRITIS; PLASMID ENCODING INTERLEUKIN-4; DOXYCYCLINE-REGULATED PLASMID; ADENOASSOCIATED VIRUS TYPE-5; NUCLEAR-LOCALIZATION SIGNAL; Genetics & Heredity

    Abstract

    Advances in molecular and cellular biology have identified a wide variety of proteins including targeted cytokine inhibitors, immunomodulatory proteins, cytotoxic mediators, angiogenesis inhibitors, and intracellular signalling molecules that could be of great benefit in the treatment of chronic joint diseases, such as osteo- and rheumatoid arthritis. Unfortunately, protein-based drugs are difficult to administer effectively. They have a high rate of turnover, requiring frequent readministration, and exposure in non-diseased tissue can lead to serious side effects. Gene transfer technologies offer methods to enhance the efficacy of protein-based therapies, enabling the body to produce these molecules locally at elevated levels for extended periods. The proof of concept of gene therapies for arthritis has been exhaustively demonstrated in multiple laboratories and in numerous animal models. This review attempts to condense these studies and to discuss the relative benefits and limitations of the methods proposed and to discuss the challenges toward translating these technologies into clinical realities.

    Journal Title

    Current Gene Therapy

    Volume

    8

    Issue/Number

    4

    Publication Date

    1-1-2008

    Document Type

    Review

    Language

    English

    First Page

    273

    Last Page

    286

    WOS Identifier

    WOS:000258744200006

    ISSN

    1566-5232

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