Death and Baxes: mechanisms of lymphotrophic cytokines

    Authors

    A. R. Khaled;S. K. Durum

    Comments

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    Abbreviated Journal Title

    Immunol. Rev.

    Keywords

    RECEPTOR-DEFICIENT MICE; T-CELL DEVELOPMENT; FORKHEAD TRANSCRIPTION; FACTOR; GAMMA GENE REARRANGEMENT; APOPTOTIC PROTEIN BAK; FAMILY MEMBER; BIM; MHC CLASS-I; INTERLEUKIN-7 RECEPTOR; BCL-2 FAMILY; HOMEOSTATIC; PROLIFERATION; Immunology

    Abstract

    In this review, we briefly cover the critical requirements for interleukin-7 (IL-7) in thymocyte development and peripheral T-cell homeostasis. Part of the IL-7 effect is antiapoptotic or 'trophic' and we have studied the intracellular pathways involved in lymphocyte survival and death regulated by this cytokine. We review the evidence for a role of the JAK signal transducers and activators of transcription protein (STAT) pathway and phosphoinositide 3-kinase (PI3K)-AKT pathways in survival. The death pathway following IL-7 withdrawal is discussed in terms of the balance of BCL-2 vs. BAX and other death proteins and the role of metabolic disturbances involving glucose metabolism and intracellular pH. The IL-7 survival and death pathways in lymphocytes may be representative of many trophic factors in different cell types; yet we conclude that much of the mechanism remains to be discovered.

    Journal Title

    Immunological Reviews

    Volume

    193

    Issue/Number

    1

    Publication Date

    1-1-2003

    Document Type

    Review

    Language

    English

    First Page

    48

    Last Page

    57

    WOS Identifier

    WOS:000182833700006

    ISSN

    0105-2896

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