A computational framework for the 3D structure determination of viruses with unknown symmetry

    Authors

    D. C. Marinescu;Y. C. Ji

    Comments

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    Abbreviated Journal Title

    J. Parallel Distrib. Comput.

    Keywords

    CRYO-ELECTRON-MICROSCOPY; 3-DIMENSIONAL RECONSTRUCTION; CRYOELECTRON; MICROSCOPY; MAXIMUM-LIKELIHOOD; MICROGRAPHS; CRYOMICROSCOPY; VISUALIZATION; PROJECTIONS; ALGORITHMS; REFINEMENT; Computer Science, Theory & Methods

    Abstract

    The protein shell of all virus structures resolved to this date exhibit some form of symmetry, most of them are spherical viruses with icosahedral symmetry; the study of viruses whose symmetry is not known, of structures which do not exhibit any symmetry, as well as the study of the genetic material of a virus are considerably more challenging. Increasing the resolution of the structure determination and solving structures with no symmetry represents a quantum leap in virus structure determination based upon electron microscopy. Computing is a major component of the structure determination process. Nowadays it is not feasible to increase the resolution of the structure determination of large macromolecules like viruses or to solve structures with no symmetry without novel parallel algorithms and environments enabling structural biologists to use parallel systems, clusters of workstations, or providing access to grid computing. (C) 2003 Elsevier Inc. All rights reserved.

    Journal Title

    Journal of Parallel and Distributed Computing

    Volume

    63

    Issue/Number

    7-8

    Publication Date

    1-1-2003

    Document Type

    Article

    Language

    English

    First Page

    738

    Last Page

    758

    WOS Identifier

    WOS:000185712100008

    ISSN

    0743-7315

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