Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women

    Authors

    B. J. Nicklas; Bwjh Penninx; A. S. Ryan; D. M. Berman; N. A. Lynch;K. E. Dennis

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    Diabetes Care

    Keywords

    OBESE POSTMENOPAUSAL WOMEN; BODY-FAT DISTRIBUTION; ABDOMINAL FAT; CARDIOVASCULAR-DISEASE; COMPUTED-TOMOGRAPHY; INSULIN SENSITIVITY; MEN; OVERWEIGHT; ACCUMULATION; FOLLOW; Endocrinology & Metabolism

    Abstract

    OBJECTIVE - This study determined whether there is a critical level of visceral adipose tissue (VAT) associated with elevated coronary heart disease (CHD) risk factors in a cohort of women > 45 years of age. RESEARCH DESIGN AND METHODS - Measurements of body composition (dual-energy X-ray absorptiometry), body fat distribution (computed tomography), fasting and 2-h postprandial (75-g) glucose concentrations, and fasting lipoprotein lipid and insulin concentrations were performed in 233 perimenopausal (9%) and postmenopausal women (age 59 - 5 years, 79% Caucasian, 16% on hormone replacement therapy). RESULTS - Women in the lowest VAT quintile (less than or equal to105 cm(2)) had higher concentrations of HDL and HDL2 cholesterol, lower LDL/HDL cholesterol ratios and triglyceride concentrations, and lower fasting glucose and insulin concentrations than women in the remaining four quintiles (P values < 0.05-0.001). Women in the second lowest VAT quintile (106-139 cm(2)) had higher HDL and HDL2 cholesterol and lower LDL/HDL ratios than women with a VAT greater than or equal to163 cm(2) (P < 0.05). Logistic regression analyses showed that women with a VAT of 106-162 cm(2) are 2.5 times more likely to have a low HDL cholesterol (P < 0.05), while women with a VAT greater than or equal to163 cm(2) are 5.5 times more likely to have a low HDL cholesterol (P < 0.01) and similar to4.0 times more likely to have a high LDL/HDL ratio (P < 0.05) compared with women with a VAT less than or equal to105 cm(2). Women with a VAT greater than or equal to163 cm(2) are at a higher risk of having impaired glucose tolerance (P < 0.01). CONCLUSIONS - A VAT greater than or equal to106 cm(2) is associated with an elevated risk, and a VAT greater than or equal to163 cm(2) with an even greater risk, for these metabolic CHD risk factors compared with women with a VAT less than or equal to105 cm(2). These values may prove useful for defining "visceral obesity" and for identifying women most likely to benefit from preventative interventions.

    Journal Title

    Diabetes Care

    Volume

    26

    Issue/Number

    5

    Publication Date

    1-1-2003

    Document Type

    Article

    Language

    English

    First Page

    1413

    Last Page

    1420

    WOS Identifier

    WOS:000185505400015

    ISSN

    0149-5992

    Share

    COinS