Field-induced reorganization of the neural membrane lipid bilayer: a proposed role in the regulation of ion-channel dynamics

    Authors

    H. Price;R. Wallace

    Comments

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    Abbreviated Journal Title

    Biosystems

    Keywords

    field-induced reorganization; electrostatic interactions; electrical; signaling; neural signaling; INFLUENZA-A VIRUS; SHAKER K+ CHANNEL; ELECTROSTATIC INTERACTIONS; BIOLOGICAL-MEMBRANES; PROTEIN INTERACTIONS; ESCHERICHIA-COLI; VOLTAGE; SENSOR; CHOLESTEROL; MODEL; PEPTIDE; Biology; Mathematical & Computational Biology

    Abstract

    We present a computational model demonstrating that an electric field propagating in the plane of the neural membrane during transmembrane ion movement creates lateral concentration gradients of the lipids. Due to this field-induced reorganization, ethenes of the lipid chains become aligned and polarized. This finding is interpreted within the context of molecular studies of protein folding in biological membranes. We propose that electrostatic interactions between membrane dipoles and charged amino acid residues of the unfolded ion-channel protein regulate protein-folding kinetics (channel closing). These electrostatic interactions thus regulate electrical signaling in neurons. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

    Journal Title

    Biosystems

    Volume

    68

    Issue/Number

    1

    Publication Date

    1-1-2003

    Document Type

    Article; Proceedings Paper

    Language

    English

    First Page

    67

    Last Page

    77

    WOS Identifier

    WOS:000182602300007

    ISSN

    0303-2647

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