Title

Field-induced reorganization of the neural membrane lipid bilayer: a proposed role in the regulation of ion-channel dynamics

Authors

Authors

H. Price;R. Wallace

Comments

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Abbreviated Journal Title

Biosystems

Keywords

field-induced reorganization; electrostatic interactions; electrical; signaling; neural signaling; INFLUENZA-A VIRUS; SHAKER K+ CHANNEL; ELECTROSTATIC INTERACTIONS; BIOLOGICAL-MEMBRANES; PROTEIN INTERACTIONS; ESCHERICHIA-COLI; VOLTAGE; SENSOR; CHOLESTEROL; MODEL; PEPTIDE; Biology; Mathematical & Computational Biology

Abstract

We present a computational model demonstrating that an electric field propagating in the plane of the neural membrane during transmembrane ion movement creates lateral concentration gradients of the lipids. Due to this field-induced reorganization, ethenes of the lipid chains become aligned and polarized. This finding is interpreted within the context of molecular studies of protein folding in biological membranes. We propose that electrostatic interactions between membrane dipoles and charged amino acid residues of the unfolded ion-channel protein regulate protein-folding kinetics (channel closing). These electrostatic interactions thus regulate electrical signaling in neurons. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Journal Title

Biosystems

Volume

68

Issue/Number

1

Publication Date

1-1-2003

Document Type

Article; Proceedings Paper

Language

English

First Page

67

Last Page

77

WOS Identifier

WOS:000182602300007

ISSN

0303-2647

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