Depression and lipoprotein lipids in healthy, postmenopausal women - The moderating effects of hormone replacement therapy

    Authors

    R. A. Brown; P. P. Giggey; K. E. Dennis;S. R. Waldstein

    Comments

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    Abbreviated Journal Title

    J. Psychosomat. Res.

    Keywords

    cholesterol; depression; hormone replacement therapy; lipoprotein lipids; LOW SERUM-CHOLESTEROL; ESTROGEN THERAPY; SYMPTOMS; MORTALITY; RISK; MEN; METAANALYSIS; SUICIDE; PLASMA; TRIAL; Psychiatry

    Abstract

    Objective: Naturally occurring low cholesterol levels have been related to increased depressive symptoms in studies conducted predominantly in men. However, depression is more common among women, may increase during the menopause, and may be impacted by hormone replacement therapy (HRT). We therefore examined the potential interactive relation of depressive symptoms and HRT status to lipoprotein lipids among postmenopausal women. Methods: Seventy healthy, postmenopausal women (ages 50-70; 36% receiving HRT) completed the Center for Epidemiological Studies Depression Scale and provided two fasting blood samples for assessment of lipoprotein lipids. Results: Following statistical adjustment for age, body mass index (BMI), HRT status, and depressive symptoms, the interaction of depression and HRT explained 16% variance in total cholesterol and 17% variance in low-density lipoprotein cholesterol (P-s < .01). Greater levels of depressive symptoms were associated with lower cholesterol levels only among women who were not taking HRT. Conclusion: These findings suggest that HRT may buffer associations between naturally occurring low cholesterol levels and increased symptoms of depression in postmenopausal women. (C) 2004 Elsevier Inc. All rights reserved.

    Journal Title

    Journal of Psychosomatic Research

    Volume

    57

    Issue/Number

    2

    Publication Date

    1-1-2004

    Document Type

    Article

    Language

    English

    First Page

    171

    Last Page

    176

    WOS Identifier

    WOS:000224761600010

    ISSN

    0022-3999

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