Effects of MgO-CaO-P2O5-Na2O-based additives on mechanical and biological properties of hydroxyapatite

    Authors

    S. J. Kalita; D. Rokusek; S. Bose; H. L. Hosick;A. Bandyopadhyay

    Comments

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    Abbreviated Journal Title

    J. Biomed. Mater. Res. Part A

    Keywords

    calcium phosphate; hydroxyapatite; sintering additives; bioactive; ceramics; bone cells; GLASS-REINFORCED HYDROXYAPATITE; SINTERING ADDITIVES; CERAMICS; BIOCERAMICS; COMPOSITES; PHOSPHATE; BONE; Engineering, Biomedical; Materials Science, Biomaterials

    Abstract

    In this research, we improved densification, hardness, and compression strength of synthetic hydroxyapatite (HAp) ceramics by introducing small quantities of MgO-CaO-P2O5-Na2O-based sintering additives. Biological properties of HAp were not altered by this procedure. Phase analyses were performed by using a Philips Xpert fully automated diffractometer with Co K-alpha radiation to understand the influence of additives on phase purity in the final products. All compositions were characterized at green and sintered densities to understand the influence of additives on densification. Some of the compositions showed > 40% increase in Vickers microhardness compared with pure HAp processed under the same conditions. Improvement in compression strength was also detected in some compositions. In vitro biological testing used a modified human osteoblast cell line to test biocompatibility, cell attachment, and cell proliferation. All these compositions were nontoxic and biocompatible. Our results indicate that MgO-CaO-P2O5-Na2O-based sintering additives can be used to improve both mechanical and biological properties of HAp ceramics. (C) 2004 Wiley Periodicals, Inc.

    Journal Title

    Journal of Biomedical Materials Research Part A

    Volume

    71A

    Issue/Number

    1

    Publication Date

    1-1-2004

    Document Type

    Article

    Language

    English

    First Page

    35

    Last Page

    44

    WOS Identifier

    WOS:000223877000005

    ISSN

    0021-9304

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