Title

Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides

Authors

Authors

J. P. Chen; S. Patil; S. Seal;J. F. McGinnis

Comments

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Abbreviated Journal Title

Nat. Nanotechnol.

Keywords

OXIDATIVE STRESS; LATTICE-DEFECTS; PIGMENT-EPITHELIUM; LIGHT-DAMAGE; THIN-FILMS; CELLS; PHOTORECEPTORS; MECHANISMS; PROTECTION; APOPTOSIS; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary

Abstract

Photoreceptor cells are incessantly bombarded with photons of light, which, along with the cells' high rate of oxygen metabolism, continuously exposes them to elevated levels of toxic reactive oxygen intermediates (ROIs). Vacancy-engineered mixed-valence-state cerium oxide nanoparticles (nanoceria particles) scavenge ROIs. Our data show that nanoceria particles prevent increases in the intracellular concentrations of ROIs in primary cell cultures of rat retina and, in vivo, prevent loss of vision due to light-induced degeneration of photoreceptor cells. These data indicate that the nanoceria particles may be effective in inhibiting the progression of ROI-induced cell death, which is thought to be involved in macular degeneration, retinitis pigmentosa and other blinding diseases, as well as the ROI-induced death of other cell types in diabetes, Alzheimer's disease, atherosclerosis, stroke and so on. The use of nanoceria particles as a direct therapy for multiple diseases represents a novel strategy and suggests that they may represent a unique platform technology.

Journal Title

Nature Nanotechnology

Volume

1

Issue/Number

2

Publication Date

1-1-2006

Document Type

Article

Language

English

First Page

142

Last Page

150

WOS Identifier

WOS:000243902600018

ISSN

1748-3387

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