Chloroplast-derived anthrax and other vaccine antigens: their immunogenic and immunoprotective properties

    Authors

    S. Kamarajugadda;H. Daniell

    Comments

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    Abbreviated Journal Title

    Expert Rev. Vaccines

    Keywords

    anthrax vaccine; chloroplast genetic engineering; genetically modified; crops; immunization; mucosal immunity; oral delivery; protective; antigens; systemic immunity; vaccines; HEAT-LABILE ENTEROTOXIN; HIGH-YIELD EXPRESSION; VP7 FUSION PROTEIN; LACTUCA-SATIVA L.; B-SUBUNIT; TRANSGENIC POTATO; TOBACCO CHLOROPLASTS; PROTECTIVE ANTIGEN; CANINE PARVOVIRUS; NEUTRALIZING ANTIBODIES; Immunology

    Abstract

    Transgenic plants offer many advantages, including low cost of production (by elimination of fermenters), storage and transportation, heat stability, absence of human pathogens, protection of antigens in the stomach through bioencapsulation (when delivered orally), elimination of the need for expensive purification and sterile injections and generation of both systemic and mucosal immunity. Recent studies have demonstrated that chloroplast-derived anthrax-protective antigen elicits effective immune responses, develops neutralizing antibodies, confers complete protection against anthrax lethal toxin challenge and produces 360 million doses of vaccine in one acre of transgenic plants. Chloroplast-derived vaccine antigens are efficacious against bacterial, fungal, viral and protozoan pathogens.

    Journal Title

    Expert Review of Vaccines

    Volume

    5

    Issue/Number

    6

    Publication Date

    1-1-2006

    Document Type

    Review

    Language

    English

    First Page

    839

    Last Page

    849

    WOS Identifier

    WOS:000243483000017

    ISSN

    1476-0584

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