Title

Patterning polymerized lipid vesicles with soft lithography

Authors

Authors

N. Mahajan; R. B. Lu; S. T. Wu;J. Y. Fang

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Langmuir

Keywords

PHOSPHOLIPID-VESICLES; IMMOBILIZATION; ORGANIZATION; ANTIBODY; BILAYERS; SYSTEMS; DNA; Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, ; Multidisciplinary

Abstract

The applications of soft lithography in patterning polymerized lipid vesicles of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine on glass substrates are reported. We demonstrate that the polymerized vesicles can be used as a high molecular weight ink to be transferred from a PDMS stamp onto a glass substrate to form two-dimensional stripes with a controlled separation. By combining channel flow with dewetting within microfluidic networks, we assemble the polymerized vesicle into three-dimensional stripes and one-dimension lines on glass substrates. Atomic force microscopy shows that these patterned vesicle structures are stable on glass substrates. The simple, stable, and precise immobilization of lipid vesicles on solid substrates will open up the possibility of integrating them in biosensors and microelectronic devices.

Journal Title

Langmuir

Volume

21

Issue/Number

7

Publication Date

1-1-2005

Document Type

Article

Language

English

First Page

3132

Last Page

3135

WOS Identifier

WOS:000228042400073

ISSN

0743-7463

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