Patterning polymerized lipid vesicles with soft lithography

    Authors

    N. Mahajan; R. B. Lu; S. T. Wu;J. Y. Fang

    Comments

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    Abbreviated Journal Title

    Langmuir

    Keywords

    PHOSPHOLIPID-VESICLES; IMMOBILIZATION; ORGANIZATION; ANTIBODY; BILAYERS; SYSTEMS; DNA; Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, ; Multidisciplinary

    Abstract

    The applications of soft lithography in patterning polymerized lipid vesicles of 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine on glass substrates are reported. We demonstrate that the polymerized vesicles can be used as a high molecular weight ink to be transferred from a PDMS stamp onto a glass substrate to form two-dimensional stripes with a controlled separation. By combining channel flow with dewetting within microfluidic networks, we assemble the polymerized vesicle into three-dimensional stripes and one-dimension lines on glass substrates. Atomic force microscopy shows that these patterned vesicle structures are stable on glass substrates. The simple, stable, and precise immobilization of lipid vesicles on solid substrates will open up the possibility of integrating them in biosensors and microelectronic devices.

    Journal Title

    Langmuir

    Volume

    21

    Issue/Number

    7

    Publication Date

    1-1-2005

    Document Type

    Article

    Language

    English

    First Page

    3132

    Last Page

    3135

    WOS Identifier

    WOS:000228042400073

    ISSN

    0743-7463

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