Title

Solid-supported synthesis of polymerizable lanthanide-ion chelating lipids for protein detection

Authors

Authors

S. Nadi; M. Santos; M. K. Haldar; B. C. Roy; S. Mallik;A. D. Campiglia

Comments

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Abbreviated Journal Title

Inorg. Chem.

Keywords

HUMAN CARBONIC-ANHYDRASE; PHASE SYNTHESIS; HIGHLY LUMINESCENT; FIBEROPTIC PROBE; LIPOSOMES; COMPLEXES; SPECTROSCOPY; TRANSFECTION; STABILITY; DELIVERY; Chemistry, Inorganic & Nuclear

Abstract

Usually, lipids are synthesized employing solution-phase organic synthesis techniques. Though successful, the purifications can be difficult to accomplish due to the amphiphilic nature of the molecules. Herein, we demonstrate the advantages of a solid-phase approach for preparing a variety of metal-chelating lipids. A number of saturated and polymerizable metal-chelating lipids were prepared using this methodology. This approach requires one chromatographic purification after cleaving the lipids from the solid support. We also demonstrate that the resulting polymerized liposomes (containing Eu3+) possess the appropriate luminescence properties for the qualitative and quantitative determination of proteins.

Journal Title

Inorganic Chemistry

Volume

44

Issue/Number

7

Publication Date

1-1-2005

Document Type

Article

Language

English

First Page

2234

Last Page

2244

WOS Identifier

WOS:000228054200018

ISSN

0020-1669

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