Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage

    Authors

    R. W. Tarnuzzer; J. Colon; S. Patil;S. Seal

    Comments

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    Abbreviated Journal Title

    Nano Lett.

    Keywords

    NANOCRYSTALLINE CERIA; NANO-PARTICLES; CELLS; Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &; Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter

    Abstract

    The ability of engineered cerium oxide nanoparticles to confer radioprotection was examined. Human normal and tumor cells were treated with nanoceria and irradiated, and cell survival was measured. Treatment of normal cells conferred almost 99% protection from radiation-induced cell death, whereas the same concentration showed almost no protection of tumor cells. For the first time, nanoceria is shown to confer radioprotection to a normal human breast line but not to a human breast tumor line, MCF-7.

    Journal Title

    Nano Letters

    Volume

    5

    Issue/Number

    12

    Publication Date

    1-1-2005

    Document Type

    Article

    Language

    English

    First Page

    2573

    Last Page

    2577

    WOS Identifier

    WOS:000234357000044

    ISSN

    1530-6984

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