Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker

    Authors

    J. S. Bedwell; L. S. Miller; J. M. Brown;N. E. Yanasak

    Comments

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    Abbreviated Journal Title

    Int. J. Neurosci.

    Keywords

    biobehavioral marker; endophenotype; first-degree relatives; functional; magnetic resonance imaging; magnocellular visual pathway; red light; TRANSIENT/MAGNOCELLULAR VISUAL-SYSTEM; POSITRON-EMISSION-TOMOGRAPHY; HEMISPHERIC-ASYMMETRY; BACKGROUND COLOR; HUMAN BRAIN; M-CHANNELS; TELL; US; PERCEPTION; MOTION; CORTEX; Neurosciences

    Abstract

    Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.

    Journal Title

    International Journal of Neuroscience

    Volume

    116

    Issue/Number

    8

    Publication Date

    1-1-2006

    Document Type

    Article

    Language

    English

    First Page

    881

    Last Page

    894

    WOS Identifier

    WOS:000239385300001

    ISSN

    0020-7454

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