Synthesis and characterization of new fluorene-based singlet oxygen sensitizers

    Authors

    K. D. Belfield; C. C. Corredor; A. R. Morales; M. A. Dessources;F. E. Hernandez

    Comments

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    Abbreviated Journal Title

    J. Fluoresc.

    Keywords

    photosensitizer; photodynamic therapy; singlet oxygen; two-photon; absorption; MOLECULAR-OXYGEN; QUANTUM YIELDS; DERIVATIVES; STATE; Biochemical Research Methods; Chemistry, Analytical; Chemistry, Physical

    Abstract

    The synthesis, photophysical characterization, and determination of singlet oxygen quantum yields (Phi(Delta)) for a class of fluorene derivatives with potential application in two-photon photodynamic therapy (PDT) is reported. It has been demonstrated that these compounds possess the ability to generate singlet oxygen (O-1(2)) upon excitation. A photochemical method, using 1,3-diphenylisobenzofuran (DPBF) as O-1(2) chemical quencher, was employed to determine the singlet oxygen quantum yields (Phi(Delta)) of the fluorene- based photosensitizers in ethanol. Phi(Delta) values ranged from 0.35 to 0.75. These derivatives may have potential application as two-photon photosensitizers when pumped via two-photon excitation in the near-IR spectral region.

    Journal Title

    Journal of Fluorescence

    Volume

    16

    Issue/Number

    1

    Publication Date

    1-1-2006

    Document Type

    Article

    Language

    English

    First Page

    105

    Last Page

    110

    WOS Identifier

    WOS:000236646200015

    ISSN

    1053-0509

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