Three-photon absorption measurements in hematoporphyrin IX: "Ground-breaking opportunities in deep photodynamic therapy"

    Authors

    I. Cohanoschi; L. Echeverria;F. E. Hernandez

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    Chem. Phys. Lett.

    Keywords

    2-PHOTON ABSORPTION; SINGLET OXYGEN; 5-AMINOLEVULINIC ACID; ONE-PHOTON; PHOTOSENSITIZERS; EXCITATION; TUMORS; ENHANCEMENT; GENERATION; PORPHYRIN; Chemistry, Physical; Physics, Atomic, Molecular & Chemical

    Abstract

    In this Letter, we report the three-photon absorption of hematoporphyrin IX (HpD-IX) in DMSO solution pumping at 1200 nm with a 25 ps pulse laser-OPG system. The obtained three-photon absorption cross-section in HpD-IX, sigma'(3) = 1.2 x 10(-78) cm(6) s(2) ph(-2), is considerably high. Because HpD-IX is one of the main constituent of Photofrine (R) II, the only approved photodynamic therapy drug by the Food and Drug Association, this result is expected to have an impact in deep bioimaging and photodynamic therapy using currently available photosensitisers. (c) 2005 Elsevier B.V. All rights reserved.

    Journal Title

    Chemical Physics Letters

    Volume

    419

    Issue/Number

    1-3

    Publication Date

    1-1-2006

    Document Type

    Article

    Language

    English

    First Page

    33

    Last Page

    36

    WOS Identifier

    WOS:000235438900007

    ISSN

    0009-2614

    Share

    COinS