Title
Overexpression of transferrin receptor and ferritin related to clinical symptoms and destabilization of human carotid plaques
Abbreviated Journal Title
Exp. Biol. Med.
Keywords
atherosclerosis; apoptosis; iron metabolism; lysosomes; macrophages; plaque rupture; HUMAN ATHEROSCLEROTIC PLAQUES; LOW-DENSITY-LIPOPROTEIN; HUMAN ATHEROMA; IRON HYPOTHESIS; DEFICIENT MICE; MACROPHAGE; EXPRESSION; RELEASE; CANCER; DAMAGE; Medicine, Research & Experimental
Abstract
Accumulation of tissue iron has been implicated in development of atherosclerotic lesions mainly because of increased iron-catalyzed oxidative injury. However, it remains unknown whether cellular iron import and storage in human atheroma are related to human atheroma development. We found that transferrin receptor 1 (TfR1), a major iron importer, is highy expressed in foamy macrophages and some smooth muscle cells in intimal lesions of human carotid atheroma, mainly in cytoplasmic accumulation patterns. In 52 human carotid atherosclerotic lesions, TfR1 expression was positively correlated with macrophage infiltration, ectopic lysosomal cathepsin L, and ferritin expression. Highly expressed TfR1 and ferritin in CD68-positive macrophages; were significantly associated with development and severity of human carotid plaques, smoking, and patient's symptoms. The findings suggest that pathologic macrophage iron metabolism may contribute to vulnerability of human atheroma, established risk factors, and their clinical symptoms. The cytoplasmic overexpression of TfR1 may be the result of lysosomal dysfunction and ectopic accumulation of lysosomal cathepsin L caused by atheroma-relevant lipids in atherogenesis.
Journal Title
Experimental Biology and Medicine
Volume
233
Issue/Number
7
Publication Date
1-1-2008
Document Type
Article
Language
English
First Page
818
Last Page
826
WOS Identifier
ISSN
1535-3702
Recommended Citation
"Overexpression of transferrin receptor and ferritin related to clinical symptoms and destabilization of human carotid plaques" (2008). Faculty Bibliography 2000s. 607.
https://stars.library.ucf.edu/facultybib2000/607
Comments
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