Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training

    Authors

    G. Ruano; R. L. Seip; A. Windemuth; S. Zollner; G. J. Tsongalis; J. Ordovas; J. Otvos; C. Bilbie; M. Miles; R. Zoeller; P. Visich; P. Gordon; T. J. Angelopoulos; L. Pescatello; N. Moyna;P. D. Thompson

    Comments

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    Abbreviated Journal Title

    Atherosclerosis

    Keywords

    apolipoprotein A1; single nucleotide polymorphism; high density; lipoprotein; subtraction; aerobic exercise; MAGNETIC-RESONANCE-SPECTROSCOPY; CORONARY-ARTERY-DISEASE; HDL-CHOLESTEROL; I GENE; PLASMA-LIPOPROTEINS; HEART-DISEASE; PROMOTER; ATHEROSCLEROSIS; POLYMORPHISM; SEDENTARY; Peripheral Vascular Disease

    Abstract

    High density lipoprotein cholesterol (HDL-C) is a primary risk factor for cardiovascular disease. Apolipoprotein A-1 (apoA1) is the major HDL-associated apolipoprotein. The -75 G/A single nucleotide polymorphism (SNP) in the apolipoprotein A1 gene (APOA1) promoter has been reported to be associated with HDL-C concentrations as well as HDL-C response to dietary changes in polyunsaturated fat intake. We examined the effect of this APOA1 SNP on exercise-induced changes in HDL subtraction distribution. From a cohort of healthy normolipidemic adults who volunteered for 6 months of supervised aerobic exercise, 75 subjects were genotyped for the -75 G/A SNP. Of these, 53 subjects were G homozygotes (G/G) and 22 were A carriers (A/G and A/A). HDL subfractions were measured by nuclear magnetic resonance (NMR) spectroscopy by adding categories HDL-C 1 + 2 for the small subfraction, and HDL-C 3 + 4 + 5 for the large. The change in total HDL-C after exercise was 0.8 +/- 17.2 mg/dL (+1.7%), and was not statistically significant. HDL subfraction amounts also did not significantly change with exercise training in the total cohort or in G homozygotes or A carriers. The amount of the large HDL subtraction increased in the G homozygotes and decreased in the A carriers (mean +/- S.E.M., 1.8 +/- 6.6 mg/dL versus -6.1 +/- 2.3 mg/dL, p < 0.0005). In contrast, the amount of the small HDL subfraction decreased in G homozygotes and increased in A carriers (-1.3 +/- 6.6 mg/dL versus 4.7 +/- 1.2 mg/dL, p < 0.005). These results show that genetic variation at the APOA1 gene promoter is associated with HDL subfraction redistribution resulting from exercise training. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

    Journal Title

    Atherosclerosis

    Volume

    185

    Issue/Number

    1

    Publication Date

    1-1-2006

    Document Type

    Article

    Language

    English

    First Page

    65

    Last Page

    69

    WOS Identifier

    WOS:000235541300008

    ISSN

    0021-9150

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