Title

Nanoparticles for bioimaging

Authors

Authors

P. Sharma; S. Brown; G. Walter; S. Santra;B. Moudgil

Comments

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Abbreviated Journal Title

Adv. Colloid Interface Sci.

Keywords

non-invasive imaging; fluorescence; magnetic resonance imaging; silica; gold; quantum dots; multimodal; nanoparticles; DOPED SILICA NANOPARTICLES; SEMICONDUCTOR QUANTUM DOTS; GREEN; FLUORESCENT PROTEIN; COLLOIDAL GOLD NANOPARTICLES; SURFACE-PLASMON; RESONANCE; OT REVERSE MICROEMULSIONS; MRI CONTRAST AGENTS; IN-VIVO; OPTICAL-PROPERTIES; MOLECULAR TOMOGRAPHY; Chemistry, Physical

Abstract

The emergence of synthesis strategies for the fabrication of nanosized contrast agents is anticipated to lead to advancements in understanding biological processes at the molecular level in addition to progress in the development of diagnostic tools and innovative therapies. Imaging agents such as fluorescent dye-doped silica nanoparticles, quantum dots and gold nanoparticles have overcome many of the limitations of conventional contrast agents (organic dyes) such as poor photostability, low quantum yield, insufficient in vitro and in vivo stability, etc. Such particulates are now being developed for absorbance and emission in the near infrared region, which is expected to allow for real time and deep tissue imaging via optical routes. Other efforts to facilitate deep tissue imaging with pre-existing technologies have lead to the development of multimodal nanoparticles which are both optical and MRI active. The main focus of this article is to provide an overview of properties and design of contrast agents such as dye-doped silica nanoparticles, quantum dots and gold nanoparticles for non-invasive bioimaging. (c) 2006 Published by Elsevier B.V.

Journal Title

Advances in Colloid and Interface Science

Volume

123

Publication Date

1-1-2006

Document Type

Review

Language

English

First Page

471

Last Page

485

WOS Identifier

WOS:000242597700034

ISSN

0001-8686

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