Nanoparticles for bioimaging

    Authors

    P. Sharma; S. Brown; G. Walter; S. Santra;B. Moudgil

    Comments

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    Abbreviated Journal Title

    Adv. Colloid Interface Sci.

    Keywords

    non-invasive imaging; fluorescence; magnetic resonance imaging; silica; gold; quantum dots; multimodal; nanoparticles; DOPED SILICA NANOPARTICLES; SEMICONDUCTOR QUANTUM DOTS; GREEN; FLUORESCENT PROTEIN; COLLOIDAL GOLD NANOPARTICLES; SURFACE-PLASMON; RESONANCE; OT REVERSE MICROEMULSIONS; MRI CONTRAST AGENTS; IN-VIVO; OPTICAL-PROPERTIES; MOLECULAR TOMOGRAPHY; Chemistry, Physical

    Abstract

    The emergence of synthesis strategies for the fabrication of nanosized contrast agents is anticipated to lead to advancements in understanding biological processes at the molecular level in addition to progress in the development of diagnostic tools and innovative therapies. Imaging agents such as fluorescent dye-doped silica nanoparticles, quantum dots and gold nanoparticles have overcome many of the limitations of conventional contrast agents (organic dyes) such as poor photostability, low quantum yield, insufficient in vitro and in vivo stability, etc. Such particulates are now being developed for absorbance and emission in the near infrared region, which is expected to allow for real time and deep tissue imaging via optical routes. Other efforts to facilitate deep tissue imaging with pre-existing technologies have lead to the development of multimodal nanoparticles which are both optical and MRI active. The main focus of this article is to provide an overview of properties and design of contrast agents such as dye-doped silica nanoparticles, quantum dots and gold nanoparticles for non-invasive bioimaging. (c) 2006 Published by Elsevier B.V.

    Journal Title

    Advances in Colloid and Interface Science

    Volume

    123

    Publication Date

    1-1-2006

    Document Type

    Review

    Language

    English

    First Page

    471

    Last Page

    485

    WOS Identifier

    WOS:000242597700034

    ISSN

    0001-8686

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