The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct

    Authors

    A. L. Cole; A. Herasimtschuk; P. Gupta; A. J. Waring; R. I. Lehrer;A. M. Cole

    Comments

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    Abbreviated Journal Title

    Immunology

    Keywords

    antimicrobial peptide; human immunodeficiency virus; acquired; immunodeficieny syndrome; microbicide; theta-defensin; vagina; THETA-DEFENSINS; VAGINAL FLUID; HIV-1; FUSION; VIABILITY; PEPTIDE; CELLS; ASSAY; Immunology

    Abstract

    Retrocyclins are cyclic antimicrobial peptides that exhibit potent activity towards a broad range of primary and laboratory-adapted strains of human immunodeficiency virus type 1 (HIV-1) in vitro. The current study shows that RC-101, an analogue of retrocyclin, prevented HIV-1 infection in an organ-like construct of human cervicovaginal tissue and retained full activity in the presence of vaginal fluid. The peptide remained within the cervicovaginal tissues throughout the 9-day incubation period without altering tissue viability, inducing damage or inducing the release of inflammatory cytokines. Collectively, these data support the potential development of RC-101 as a topical microbicide to prevent HIV-1 infection and transmission.

    Journal Title

    Immunology

    Volume

    121

    Issue/Number

    1

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    140

    Last Page

    145

    WOS Identifier

    WOS:000245399800014

    ISSN

    0019-2805

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