Title

Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons

Authors

Authors

M. Das; S. Patil; N. Bhargava; J. F. Kang; L. M. Riedel; S. Seal;J. J. Hickman

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Biomaterials

Keywords

adult spinal cord neurons; auto-catalytic; cerium oxide; nanoparticle; neuroprotection; nerve regeneration; SERUM-FREE MEDIUM; HIPPOCAMPAL-NEURONS; DEFINED SYSTEM; ORGANOSILANE; SURFACE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; NANO-PARTICLES; CELL-DEATH; CULTURE; PROTECTION; Engineering, Biomedical; Materials Science, Biomaterials

Abstract

This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles. (c) 2006 Elsevier Ltd. All rights reserved.

Journal Title

Biomaterials

Volume

28

Issue/Number

10

Publication Date

1-1-2007

Document Type

Article

Language

English

First Page

1918

Last Page

1925

WOS Identifier

WOS:000244436000019

ISSN

0142-9612

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