Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons

    Authors

    M. Das; S. Patil; N. Bhargava; J. F. Kang; L. M. Riedel; S. Seal;J. J. Hickman

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    Biomaterials

    Keywords

    adult spinal cord neurons; auto-catalytic; cerium oxide; nanoparticle; neuroprotection; nerve regeneration; SERUM-FREE MEDIUM; HIPPOCAMPAL-NEURONS; DEFINED SYSTEM; ORGANOSILANE; SURFACE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; NANO-PARTICLES; CELL-DEATH; CULTURE; PROTECTION; Engineering, Biomedical; Materials Science, Biomaterials

    Abstract

    This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles. (c) 2006 Elsevier Ltd. All rights reserved.

    Journal Title

    Biomaterials

    Volume

    28

    Issue/Number

    10

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    1918

    Last Page

    1925

    WOS Identifier

    WOS:000244436000019

    ISSN

    0142-9612

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