Interfinking interleukin-7

    Authors

    C. Kittipatarin;A. R. Khaled

    Comments

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    Abbreviated Journal Title

    Cytokine

    Keywords

    cytokine; proliferation; lymphocytes; homeostasis; metabolism; T-CELL PROLIFERATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; RECEPTOR-DEFICIENT; MICE; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL-TRANSDUCTION; CYCLE; PROGRESSION; PHOSPHATIDYLINOSITOL 3-KINASE; LYMPHOID DEVELOPMENT; SURVIVAL SIGNALS; GENE-EXPRESSION; Biochemistry & Molecular Biology; Cell Biology; Immunology

    Abstract

    The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and result in their self-renewal largely remain to be elucidated. Much focus has been placed on the anti-apoptotic function of the cytokine, interleukin-7 (IL-7), during T-cell development. But a more critical role has been ascribed to IL-7 as a mediator of peripheral T-cell maintenance. The biological effects responsive to IL-7 signaling are transduced through only a few well-known pathways. In this review we will focus on the signals transduced by IL-7 and similar cytokines, examining how proliferative signals originate from cytokine receptors, are amplified and eventually alter gene expression. In this regard we will highlight the crosstalk between pathways that promote survival, drive cell cycle progression and most importantly provide the needed energy to sustain these critical cellular activities. Though this review showcases much of what has been learned about IL-7 proliferative signaling, it also reveals the significant gaps in our knowledge about cytokine signaling in the very relevant context of peripheral T-cell homeostasis. (C) 2007 Elsevier Ltd. All rights reserved.

    Journal Title

    Cytokine

    Volume

    39

    Issue/Number

    1

    Publication Date

    1-1-2007

    Document Type

    Review

    Language

    English

    First Page

    75

    Last Page

    83

    WOS Identifier

    WOS:000250421500181

    ISSN

    1043-4666

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