Title
Diacyltrehalose of Mycobacterium tuberculosis inhibits lipopolysaccharide- and mycobacteria-induced proinflammatory cytokine production in human monocytic cells
Abbreviated Journal Title
FEMS Microbiol. Lett.
Keywords
Mycobacterium tuberculosis; diacyltrehalose; cytokines; monocytes; TOLL-LIKE RECEPTORS; PULMONARY TUBERCULOSIS; T-CELLS; ANTIGEN; LIPOARABINOMANNANS; INTERLEUKIN-12; MACROPHAGES; ACTIVATION; IMMUNITY; IL-12; Microbiology
Abstract
The lipids located in the outer layer of Mycobacterium tuberculosis, which include sulfolipid, phthiocerol dimycocerosate (PDIM), diacyltrehalose, and polyacyltrehalose, may play a role in host-pathogen interactions. These lipids were purified using thin-layer chromatography, and their ability to induce proinflammatory cytokines in human monocytes and in a human acute monocytic leukemia cell line (THP-1) was examined. None of the lipids tested induced significant interleukin (IL)-12p40 or tumor necrosis factor (TNF)-alpha production in monocytic cells. Diacyltrehalose significantly inhibited lipopolysaccharide- and M. tuberculosis-induced IL-12p40, TNF-alpha, and IL-6 productions in human monocytes, whereas other lipids had no effect. However, diacyltrehalose was unable to inhibit peptidoglycan-induced IL-12p40 production. These results suggest that diacyltrehalose is a mycobacterial factor capable of modulating host immune responses.
Journal Title
Fems Microbiology Letters
Volume
267
Issue/Number
1
Publication Date
1-1-2007
Document Type
Article
Language
English
First Page
121
Last Page
128
WOS Identifier
ISSN
0378-1097
Recommended Citation
"Diacyltrehalose of Mycobacterium tuberculosis inhibits lipopolysaccharide- and mycobacteria-induced proinflammatory cytokine production in human monocytic cells" (2007). Faculty Bibliography 2000s. 7343.
https://stars.library.ucf.edu/facultybib2000/7343
Comments
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