Influence of polymer-pore interactions on translocation

    Authors

    K. Luo; T. Ala-Nissila; S. C. Ying;A. Bhattacharya

    Comments

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    Abbreviated Journal Title

    Phys. Rev. Lett.

    Keywords

    FACILITATED MEMBRANE-TRANSPORT; MONTE-CARLO-SIMULATION; POLYNUCLEOTIDE; MOLECULES; DNA TRANSPORT; NANOPORE; DRIVEN; DYNAMICS; CHANNEL; DISCRIMINATION; CHAIN; Physics, Multidisciplinary

    Abstract

    We investigate the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. An attractive interaction can greatly improve the translocation probability. At the same time, it also increases the translocation time slowly for a weak attraction while an exponential dependence is observed for a strong attraction. For fixed driving force and chain length the histogram of translocation time has a transition from Gaussian distribution to long-tailed distribution with increasing attraction. Under a weak driving force and a strong attractive force, both the translocation time and the residence time in the pore show a nonmonotonic behavior as a function of the chain length. Our simulations results are in good agreement with recent experimental data.

    Journal Title

    Physical Review Letters

    Volume

    99

    Issue/Number

    14

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    4

    WOS Identifier

    WOS:000249974000078

    ISSN

    0031-9007

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